S-STEM Scholar Charlene Bell's Blog

  DHDDS Dehydrodolichyl diphosphate synthase complex subunit DHDDS With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). BARD1 BRCA1-associated RING domain protein 1 E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repa...

 1. Pirin: Pirin This family consists of Pirin proteins from both eukaryotes and prokaryotes. The function of Pirin i... Accession: pfam02678 ID: 396999   2. cupin_RmlC-like: RmlC-like cupin superfamily This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydro... Accession: cl40423 ID: 424065   3. cupin_Yhhw_C: Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, C-terminal cupin domain This family includes the C-terminal domain of YhhW and YhaK, Escherichia coli pirin-like proteins wi... Accession: cd20311 ID: 380445   4. cupin_pirin-like_C: pirin-like, C-terminal cupin domain This family contains the C-terminal cupin domain of pirin and pirin-like proteins, including Escheri... Accession: cd20288 ID: 380422   5. cupin_pirin-like_N: pirin-like, N-terminal cupin domain This family contains the N-terminal cupin domain of pirin and pirin-like proteins, including Escheri... Accession: cd20287 ID: 380421...